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However, there have been occasional reports of headaches, dizziness, and blurred vision as well as gastrointestinal side effects. Since all trials lasted 36 weeks or less, long-term safety is unknown.
In addition, there's a lack of long-term safety data — most studies have lasted three months or less — and many participants in the trials had side effects, including nausea and vomiting.
View abstract. Ma, x. , tan, c. , zhu, d. , and gang, d. R. A survey of potential huperzine a natural resources in china: the huperziaceae.
Ma x, tan c, zhu d, gang dr. A survey of potential huperzine a natural resources in china: the huperziaceae. J ethnopharmacol. 2006;104(1-2):54-67. 16203116.
While research on the health effects of huperzine a is limited, there's some evidence that huperzine a may offer certain benefits. Here's a look at some key findings from the available research:.
Due to a lack of supporting research, huperzine a cannot currently be recommended for treatment or prevention of any health problem. If you're considering the use of huperzine a supplements, consult your doctor before starting your supplement regime to weigh the risks, benefits, and appropriateness.
Every time i do this, i notice the lack of this nootropic in my system and upon start. Reap all the benefits!. I tried huperzine a because i had been having difficulty recalling little things like names of people and details ov events.
Keywords were “huperzine a” (or its trademark names in china such as ha bo yin, shuang yi ping) and “alzheimer’s disease” or “vascular dementia” and the limits were rcts and human.
Pregnancy and breast-feeding: there isn't enough reliable information to know if huperzine a is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Back to top. Huperzine a is a substance extracted from a plant called chinese club moss (huperzia serrata). In traditional chinese medicine , chinese club moss has long been used to reduce inflammation and to sharpen memory.
. Will huperzine a improve my workout?. Huperzine a is used in bodybuilding as a nootropic, meaning it boosts focus. It is touted as a workout enhancer and included in several combination supplements.
Chem biol interact. 9-25-2008;175(1-3):380-386. View abstract. Hameda, a. B. , elosta, s. , and havel, j. Optimization of the capillary zone electrophoresis method for huperzine a determination using experimental design and artificial neural networks.
Improves focus and concentration and overall cognitive function. Most of the huperzine a benefits result from the increased acetylcholine production following supplementation. It is not only a powerful nootropic but an excellent choice for bodybuilders and fitness enthusiasts.
Side effects of the medication and the benefits and side effects of. Huperzine a. Once a person has a full understanding of how each of these.
Huperzine a has improved acetylcholine levels in animal and human studies and influences cholinesterase enzyme activity. *3-6 the net effect is an increase in acetylcholine. * this involvement with acetylcholine signaling might explain its reported benefits on memory and cognition.
Huperzine a might offer other benefits. It has a reputation for increasing rem sleep (dreaming stage of sleep) and lucid dreaming*—this reputational effect has not been studied but would presumably be related to acetylcholine.
V rispoli et al. , “huperzine a restores cortico-hippocampal functional connectivity after bilateral ampa lesion of the nucleus basalis of meynert”, j alzheimers dis. 2013;35(4):833–46. Hy zhang, “new insights into huperzine a for the treatment of alzheimer’s disease”, acta pharmacol sin.
Studies on huperzine-a and alzheimers show positive links and benefits. Currently, there is no absolute cure for alzheimer’s, but there are treatments that lessen and stabilize symptoms.
Alz. Org/alzheimers_disease_alternative_treatments. Asp. Accessed oct. 15, 2017. Laver k, et al. Interventions to delay functional decline in people with dementia: a systematic review of systematic reviews.
Curr top med chem. 2007;7(4):375-87. [ pubmed:17305579 ]. Akhondzadeh s, abbasi sh: herbal medicine in the treatment of alzheimer's disease. Am j alzheimers dis other demen.
Ann n y acad sci 9-24-1993;695:304-306. View abstract. Hao, z. , liu, m. , liu, z. , and lv, d. Huperzine a for vascular dementia. J control release 10-20-2005;107(3):417-427.
No studies have tested whether huperzine a can prevent dementia or cognitive decline. Huperzine a supplements are often promoted as nootropic (i. E. , promoting cognitive function) but a quasi-randomized double-blind study of 84 healthy individuals in the military reported that huperzine a did not improve cognitive function.
Huperzine a appears to be of some benefit to people with alzheimer's disease, according to a 2013 research review published in plos one. researchers searched for all randomized controlled trials on the efficacy and safety of huperzine a for alzheimer's disease and concluded that huperzine a was more effective than a placebo in terms of its effects on cognitive function, behavioral disturbance, and functional performance.
Very few studies have tested the use of huperzine a for memory enhancement. However, an older, small study published in the chinese journal acta pharmacologica sinica in 1999 found that huperzine a helped improve memory and learning in a group of adolescent students.
Huperzine a (1) also exhibits impressive beneficial effects for the pretreatment of organophosphate poisoning (112). Huperzine b (2) is a potential agent for ad, and may be beneficial in vascular dementia and other neurodegenerative disorders with an ischemic component (113).
But what does the science actually say about this plant-based supplement? read on to learn more about huperzine a, its potential effects, and how it might work!.
Since huperzine a and common alzheimer's disease drugs such as aricept behave similarly, it may exacerbate the side effects of these drugs. It may also reduce the effectiveness of other drugs with anti-cholinergic effects such as some anti-histamines and anti-depressants.
, 2008). Antagonizing effects of hupa on n-methyl-d-aspartate receptors and potassium currents may also contribute to its neuroprotection as well. Hupa improves cognitive deficits in a broad range of animal models (fig.
, 2012 ). Antagonizing effects on n-methyl-d-aspartate receptors. Synaptic plasticity, the variable efficacy of neurotransmission at synapses, is thought to underlie the ability of the brain to store memories (martin et al.
Huperzine a may cause side effects including nausea, diarrhea, vomiting, dry mouth, constipation, sweating, blurred vision, slurred speech, fainting, restlessness, loss of appetite, contraction and twitching of muscle fibers, cramping, increased saliva and urine, inability to control urination, high blood pressure, swelling, dizziness, inability to sleep, and slowed heart rate.
Indeed, the addition of huperzine a may raise the risk of side effects. Serious side effects have not been reported in the small clinical trials completed for huperzine a.
Huperzine a is commonly used as an ingredient in nootropic supplements and is found naturally in chinese club moss huperzia serrata, from which the nootropic gets its name.
J ethnopharmacol. 3-8-2006;104(1-2):54-67. View abstract. Ma, x. , tan, c. , zhu, d. , and gang, d. R. Is there a better source of huperzine a than huperzia serrata? huperzine a content of huperziaceae species in china.
Huperzine a acts as a cholinesterase inhibitor — a type of medication that works by improving the levels of neurotransmitters in the brain. Small early studies suggest that huperzine a might improve memory and protect nerve cells, which could slow the cognitive decline associated with alzheimer's.
According to one study, huperzine a may work in similar ways to some alzheimer’s disease medications which are also believed to affect the acetylcholine system of the brain, such as donepezil, rivastigmine, tacrine, and galantamine – although with fewer side effects and somewhat more favorable pharmacokinetics [ 8 ].
But how do we remedy the situation? this is where huperzine a comes to the rescue. Huperzine a is an inhibitor for ache (the bad guy). So, whenever you take it, it hinders the enzyme from doing its unsolicited work.
Studies show hup-a not only prevents this drop in ngf from happening. It actually helps boost the production of ngf. [viii]. How does huperzine-a feel?.
Your body has the potential to build a tolerance to substances with a long half-life, meaning that you’ll need a greater huperzine a dosage each time to feel the same effects (until the substance has been cleared from your body).
. Little is known about the safety of taking huperzine a in the long term. There is some concern that the use of huperzine a may be harmful to people with certain health conditions, including kidney and/or liver disorders, heart disease, asthma , epilepsy , and vertigo.
Huperzine a may interact with certain medications including cholinesterase inhibitors, beta-blockers, and anti-convulsive agents. given these safety concerns, it's important to consult your physician if you're considering the use of huperzine a.
A growing number of studies are looking into the huperzine a benefits on otherwise healthy people. In these studies, scientists have found similar effects. For example, a study conducted on 34 pairs of adolescent students found that huperzine a capsules enhanced both memory and learning performance.
Finally, a third study indicated that huperzine a has protective effects against the free-radical, h2o2 (hydrogen peroxide). The researchers also stated that huperzine a benefits include protection against glutamate, beta-amlyoid proteins, ischema, and staurosporine toxicity.
It’s safe, well-tolerated, and non-toxic when taken in moderation. If you’re interested in a reliable, affordable nootropic that can boost your memory while it helps maintain optimal brain health, huperzine a may be a good addition to your stack.